I'd recommend doing it on emunand first. Doing it to sysnand directly is probably a bad idea. If emunand boots after you region change it, then it should work on sysnand.
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AquaX101
I would on emunand but I don't own a gateway and I tried to inject the secureinfo_a 25 times after i installed the system cias on palantines cfw and it would get stuck at "Writing EmuNAND". then I made a emunand on my other SD and it injected perfectly fine on the first try and this is without palantine cfw.
Apache Thunder
You'll have to convert the emunand you did get it working on to a cfw compatible one, then install the correct region cias. Check that it boots, then extract and convert back to normal nand image.
AquaX101
CFW EmuNAND doesn't extract from the sd card from emunand tool, I know how to extract it using hex workshop, so i'll do that. But how would I convert it back to the normal nand image?
Apache Thunder
Dump the SD card using Disk Imager (the tool NAND modders usually use). Then use hex editor to remove part of the first sector and delete the non emunand data. You can look at an existing nand dump you have in your hex editor to see where the nand image starts and ends in your full SD dump. Then you'll have your cfw emunand converted back.
Apache Thunder
You will need to reformat the SD card and setup emunand again with Gateway menu before you can inject it back for testing as CFW has altered the size of the partition.
AquaX101
I'm new with Disk Imager, how do I dump the sd using it?
Apache Thunder
You hit the read button. You have to specify a file first. Just point it to a folder location you want to save the image to. Then hit read.
AquaX101
So I opened the image in the hex editor, do I delete everything leading up to NCSD including NCSD? http://i.imgur.com/CrLldh7.png
Apache Thunder
It's been awhile since I've done this. Unfortunately I can't tell you exactly where it starts because I no longer have a CFW emunand. I suggest you search the forum/post in an existing thread asking about this as this is as far as I can take you on this. Sorry.
AquaX101
Got it to work! So now is it safe for me to backup the emunand using emunand tool and then restore it to the sysnand using gateway 3.1.1?
Apache Thunder
Should be. Assuming it was 4.x fw then it should work on sysnand. NATIVE_FIRM doesn't have to be installed in this case as it's the same title ID for all regions, so I would assume the one you had before will work. Since NATIVE_FIRM wasn't altered, you won't have brick issues. If emunand boots, then it should boot on sysnand assuming you had injected the new region SecureInfo file already.
AquaX101
Alright one more question, can i restore back between europe and us nands back and forth if I need to?
Apache Thunder
Yeah, if both NAND are already setup you can swap. Though I think it easier to swap back and forth via emunand. 
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BigOnYa:
I've been playing fallout4 all day, I went into a elevator and it kept going, never stopped, waited 5 minutes, must of been a bug. How bout you, whatcha do today?+1 -
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MysticStarlight:
Ah yes, that guy lol. I still need to find all his signs. The game has a lot to do though so I don't know what to finish first -
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BigOnYa:
Good times. Building is starting to get good around now for you. You making me want to make run thru again.
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BigOnYa:
Ok good chatting, enjoy your gaming, and avoid the lightning, or put your sword away. Good night.
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Injecting the different region secure info file without installing the correct region cias for it will result in a brick.