Hello everyone. I also encountered this problem and managed to work around it. I hope my case will help someone.
At first I played on GBA SP AGS-101. When the game froze just before the explosion at the end, I tried again and again with different settings, but nothing helped. Then I came across...
I've been playing fallout4 all day, I went into a elevator and it kept going, never stopped, waited 5 minutes, must of been a bug. How bout you, whatcha do today?