Personally, I wouldn't; I think the extreme attention to detail - the main character actually reaching for natural resources or to open cupboards, etc., is far too slow for what is, in the end, a videogame; other games skip this bit of realism to speed up or even skip repetitive tasks, thereby enhancing game flow.
Additionally, while you can kill animals and sell their corpses, the main character has to physically carry the kill to his horse, and has to reach town before the carcass rots; there's also various ranks of carcasses, too, with better (and rarer) ones selling for more. Again, this level of realism is unnecessary, as it doesn't allow for player freedom; other games just have you kill an animal, skin them, store the skin and other resources in your inventory, and you can sell the stuff whenever you want.
Oh, and there's no singleplayer DLC, since RockStar focused on the online multiplayer...which, last I heard, was suffering heavily. Might even be abandoned now, for all I know. RockStar even tried to force in Shard Card-esque monetisation, making stuff ludicrously expensive for the minuscule amount of gold you earn in MP.